Purpura trombocitopenica fisiopatologia pdf

Thrombotic thrombocitopenic purpura is a rare disease with a morphological expression featured of many microthrombi in the terminal arterioles of several vital structures. Idiopathic thombocytopenic purpura itp is an autoimmune. Trombocitopenia inmune primaria pediatria integral. Esta enfermedad afecta a varones y a mujeres por igual. Approach to the investigation and management of immune thrombocytopenic purpura in children. Purpura is a disease in which there is leakage of blood out of the blood vessels in the skin or mucosa, causing the presence of painless purplish spots, called petechiae small and large number stains or ecchymoses larger patches. Moschcowitz was the first to inform multiple hyaline thrombi as the primordial finding of a partial autopsy case. Thrombotic thrombocytopenic purpura ttp is the most extensive and dangerous intravascular platelet clumping disorder. Klaassen rj, blanchette vs, barnard d, wakefield cd, curtis c, bradley cs, et al. For more than a halfcentury after its initial recognition, mortality was near 100% and the etiology totally obscure. He proposed that a powerful poison with both agglutina. Mecanismos celulares y bioquimicos involucrados en. Fisiopatologia da ptt a fisiopatologia da ptt foi elucidada em 1982 por joel moake et al. Purpura trombocitopenica, plaquetas, purpura, autoanticuerpos.

Purpura results from the extravasation of blood cells into the skin andor mucous membranes giving rise to small purple coloured areas that do not disappear under pressure. Clase 49 purpura trombocitopenica idiopatica aguda youtube. Thrombocytopenic purpura is mostly responsible for episodes of mucocutaneous bleeding. It can produced in health people, but in children has been associated to viral infection, or bacterial infection. Purpura trombotica trombocitopenica y sindrome hemolitico uremico. Validity, reliability, and responsiveness of a new measure of healthrelated quality of life in children with immune thrombocytopenic purpura. The etiopathogenic mechanisms may result from abnormalities in any of the three components of hemostasis.

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